Falling Walls Lab Winner’s Spotlight: Unathi Ramashala – Breaking the Wall of Breast Cancer Models

From Johannesburg to Berlin, Unathi Ramashala is preparing to bring a powerful message to the world stage: breast cancer research must represent African women. Her project, “Breaking the Wall of Breast Cancer Models,” took first place at Falling Walls Lab Johannesburg 2025, earning her a coveted spot among the world’s top young innovators who will compete at Falling Walls Lab Berlin this November.

Unathi’s work tackles a critical gap in global cancer research. Most current breast cancer models are based on Caucasian populations and rely on 2D cell cultures, flat monolayers that fail to mimic the natural structure and diversity of real tumours. This lack of representation and realism leads to inadequate care and poorer outcomes for African patients.

Her team is developing 3D organoid cultures, miniature tumour models derived directly from Black South African women, to preserve the original genetics and behaviour of patients’ tumours. By establishing a biobank of African patient-derived breast cancer organoids, Unathi aims to transform breast cancer research and treatment for communities too often left behind.

Reflecting on the Johannesburg Lab, Unathi said:

“My experience at the Falling Walls Lab Johannesburg 2025 has been truly profound. The opportunity challenged me to summarise and pitch my project in just under three minutes. Because of this, I’ve gained confidence, clarity, and a renewed passion. The event itself was a pleasure, filled with inspiring ideas from young, passionate minds. I had the chance to network and catch a glimpse of the incredible work being done to break walls and uplift communities through scientific innovation from multiple disciplines. I’d highly encourage students and professionals to consider applying for Falling Walls Lab in the future, your ideas have the potential to break walls.”

As Unathi hones her presentation and prepares to represent South Africa’s innovation community in Berlin, her journey highlights the global importance of inclusive research and the ability of African science to shape worldwide healthcare.

Stay tuned as we follow her path to Berlin, proof that groundbreaking science born in South Africa can inspire and impact the world.